As with primaquine, tafenoquine can cause severe hemolytic anemia in people with G6PD deficiency. Those with partial deficiency that may be missed by qualitative testing may also be at risk for hemolysis. Hydroxychloroquine generic price Hydroxychloroquine copay assistance Plaquenil interactions herbs If used for the radical cure of P. vivax malaria, Krintafel tafenoquine should be co-administered with chloroquine only. This is a change from the original Krintafel labeling that allowed for use of Krintafel in combination with other antimalarials artemether-lumefantrine, atovaquone-proguanil, quinine plus doxycycline. Tafenoquine belongs to a group of medicines, called antiprotozoals. It works by treating malaria, a red blood cell infection transmitted by the bite of a mosquito. It also prevents the development of the blood forms of the parasite, which are responsible for the relapse. Tafenoquine is available only with your doctor's prescription. Chloroquine resistance was confirmed in the case of one early recurrence and has been reported to occur in the geographic regions included the trial. 28-30 A phase 3 trial is assessing tafenoquine. Tafenoquine use in people with G6PD deficiency or unknown G6PD status is contraindicated. Therefore, physicians must perform G6PD testing before prescribing tafenoquine. Act with chloroquine tafenoquine Guidance for Using Tafenoquine for Prevention and Antirelapse., Tafenoquine Advanced Patient Information - G6pd chloroquineChloroquine sle doseAralen animePlaquenil and kidney disease Tafenoquine an 8-aminoquinoline was approved by the Food and Drug Administration FDA in 2018 for the radical cure of Plasmodium vivax malaria and preventive action against malaria. Despite the fact that the mechanism of action of the drug remains unclear, all studies indicated that a metabolite is responsible for its efficacy. Tafenoquine A 2018 Novel FDA-Approved Prodrug for the.. Single-Dose Tafenoquine to Prevent Relapse of Plasmodium.. Efficacy and Safety Study of Tafenoquine TQ Co-administered.. The use of a medicine that targets the dormant liver form of the parasite, co-administered with currently available antimalarials such as chloroquine or artemisinin-based combination therapies ACTs is known as the radical cure. Tafenoquine succinate equivalent to 150 mg tafenoquine base. The proposed dosing regimen involves oral administration of 300 mg, co-administered with chloroquine once on the first or second day of the three days chloroquine administration, to patients tested for glucose-6-phosphate dehydrogenase G6PD. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated.