Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Simple synthesis of chloroquine Plaquenil and rheumatoid nodules Lupus drug plaquenil Chloroquine and Hydroxychloroquine Toxicity PH 1200 x 630 FB Featured Image.013 Background Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with different therapeutic and toxic doses with similar clinical indications for use and manifestations of retinal toxicity. In some people, Plaquenil can cause a condition called hydroxychloroquine retinopathy, often referred to as bulls-eye maculopathy. The condition sometimes resembles a target, or bulls-eye ring, on the retina surrounding the macula. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Eye retinal toxicity dosage hydroxychloroquine Has anyone experienced plaquenil toxicity with damage to eyes?, Plaquenil Side Effects on Your Eyes and Vision Plaquenil sulfateDoes hydroxychloroquine treat fibromyalgia Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Hydroxychloroquine-Induced Retinal Toxicity - American Academy of.. What can Hydroxychloroquine Plaquenil do to my eyes?. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening. Like all medicines, it can cause side effects. Hydroxychloroquine retinopathy It is known that some people who take hydroxychloroquine for more than five years and/or in high doses are at increased risk of damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as retinal toxicity or retinopathy. After losing a significant amount of weight without adjusting her dosage, she developed hydroxychloroquine toxicity, which produced a central scotoma in her right eye. She also underwent successful laser retinopexy for a retinal tear in 2011 in the right eye, followed by a vitrectomy for an idiopathic retinal hemorrhage in 2013. It’s generally safe at normal doses, but higher amounts can damage the retina, the light-sensitive tissue at the back of the eye, and result in partial or complete blindness. Hydroxychloroquine-related eye problems were once considered rare, but better detection methods now show that they occur in about 7 percent of patients.