Why chloroquine start with loading dose

Discussion in 'Plaquenil Generic' started by filimon2008, 19-Mar-2020.

  1. Cybeer Well-Known Member

    Why chloroquine start with loading dose


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. -Each dose should be taken with a meal or a glass of milk.

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    Dosage. Chloroquine can be administered either orally or parenterally for treatment of malaria, but prophylaxis is given in tablet form. An effective blood concentration is reached within 2-3 hours if a loading dose of 600 mg base is used. The therapeutically effective plasma concentration is 15-30 m g base/liter. The dose of chloroquine is often expressed or calculated as the base each 500 mg tablet of chloroquine phosphate is equivalent to 300 mg chloroquine base. -The pediatric dose should never exceed the adult dose. Nov 25, 2019 To treat malaria Chloroquine is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. To treat amebiasis Chloroquine is given in a high starting dose for 2 days followed by a smaller dose for 2 to 3 weeks. You may be given other medications to help prevent further infection.

    -Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria. Use: Malaria prophylaxis Acute attack: 800 mg (620 mg base) orally followed in 6 to 8 hours by 400 mg (310 mg base), then 400 mg (310 mg base) once a day for 2 consecutive days; alternatively, a single dose of 800 mg (620 mg base) has also been effective Alternate dosing based on body weight: A total dose representing 25 mg/kg is administered in 3 days, as follows: First dose: 10 mg base/kg (not to exceed 620 mg base) orally Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose Third dose: 5 mg base/kg orally 18 hours after second dose Fourth dose: 5 mg base/kg orally 24 hours after third dose Comments: -Each dose should be taken with a meal or a glass of milk.

    Why chloroquine start with loading dose

    Chloroquine MedlinePlus Drug Information, Chloroquine Dosage Guide with Precautions -

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  4. The efficacy of a loading dose of 20 mg of chloroquine per kg of body weight per os given at intervals during the first day was evaluated in 27 patients in Madagascar with Plasmodium falciparum malaria.

    • Efficacy of a loading dose of oral chloroquine in a 36-hour..
    • Chloroquine Uses, Side Effects & Warnings -.
    • Loading Drug Dose - an overview ScienceDirect Topics.

    The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in 11 lactating mothers following a single oral dose of chloroquine 600 mg basemaximum daily dose of the drug that the infant received from breast-feeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults. Why administer a vancomycin loading dose? Due to the pharmacokinetics of vancomycin, a loading dose – a large dose given once at the onset of therapy to rapidly achieve a therapeutic drug concentration in the body – is required to ensure that vancomycin levels are not subtherapeutic at the beginning of treatment. 6,7

     
  5. Raiv New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine drug Britannica Chloroquine Indications, Side Effects, Warnings - Chloroquine Oral Uses, Side Effects, Interactions.
     
  6. xAndroniCx Moderator

    Hydroxychloroquine is a member of the antimalarial quinolines drug class and is commonly used for COVID-19, Dermatomyositis, Lyme Disease - Arthritis, and others. The cost for hydroxychloroquine oral tablet 200 mg is around for a supply of 50, depending on the pharmacy you visit. Prescription Discount Card - GoodRx Save on Prescription Drugs with Save. Health Plaquenil Coupon 2020 - New - Free Rx Discount Card
     
  7. Anttuan Well-Known Member

    Will you have Urinary tract infection with Plaquenil - eHealthMe Urinary tract infection is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain

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