Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil headache Side effects of chloroquine drugs Chloroquine diphosphate dmem Hydroxychloroquine metallic taste Joint pain and muscle pain; Headache; In about 20% of cases, the infection can attack the nervous system. This can cause very bad headache and stiff neck, paralysis of the muscles of the face or painful inflammation of nerves. Fibromyalgia is sometimes misdiagnosed as Lyme disease, but patients with fibromyalgia generally have diffuse pain, and they lack objective evidence of joint inflammation. Other inflammatory arthritides, such as rheumatoid arthritis, reactive arthritis, or psoriatic arthritis may develop within months after Lyme disease, seemingly triggered by the spirochetal infection. Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil lyme joint pain Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Diagnosis and Treatment of Lyme Arthritis Arthritis medication hydroxychloroquineHalf life of hydroxychloroquine sulfatePlaquenil retinal depositsIs chloroquine toxic to cellsPlaquenil 200mg prospect I was on Plaquenil for about 6 months, but it was because I was diagnosed with seronegative RA. It did actually relieve a little of my joint pain, but I still had other numerous problems, blurred vision, migraines, IBS, pins and needles, and chronic fatigue. Plaquenil and lyme treatment - Lyme Disease - MedHelp. Plaquenil and pain" Rheumatoid Arthritis Community.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. The symptoms of second stage, early disseminated, Lyme disease can be difficult to attribute. Symptoms include severe fatigue, fever, pain, intermittent weakness and achiness of the muscles and joints, numbness in arms and legs, vision changes, and cognitive dysfunction such as short-term. Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Jul 15, 2006 l have been taking plaquenil for 7 years now, at first it really helped me, l never had any side effect and l went into remission for 5 1/2 years with no pain, but unfortunately the pain started to come back last year, my RA doctor added methotrexate with my plaquenil and its been 8 months now and l haven't had any improvement in fact it is.