Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine lupus Plaquenil dose by weight Buy hydroxychloroquine Feb 12, 2020 1. Parasit Vectors. 2020 Feb 12;13167. doi 10.1186/s13071-020-3934-5. Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination. Malaria is more common in rural areas than in cities. For example, several cities in the Greater Mekong Subregion of Southeast Asia are essentially malaria-free, but the disease is prevalent in many rural regions, including along international borders and forest fringes. Liminating Malaria in the Greater Mekong Subregion 2 United to end a deadly disease support and accelerating progress. But even as this work was under way, additional pockets of resistance emerged independently in new geographic areas of the subregion. In parallel, there were reports of increased resistance to ACT partner drugs in some settings. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. 1950s chloroquine resistance greater mekong subregion Chloroquine - Wikipedia, Malaria - Wikipedia Is hydroxychloroquine a sulfa drug Resistance to chloroquine surfaced here in the 1950s before sweeping through the wider Mekong region and then into India and Africa, causing millions of deaths. Sulfadoxine-pyrimethamine went next. Drug resistance triggers war to wipe out malaria in the.. TO END A DEADLY DISEASE - int. Increasing trends of malaria in a border area of the.. The emergence and spread of fit artemisinin-resistant P falciparum parasite lineages, which then acquire partner drug resistance across the Greater Mekong subregion, threatens regional malaria control and elimination goals. Elimination of falciparum malaria from this region should be accelerated while available antimalarial drugs still remain. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. The expert group recommends increased surveillance in the Mekong, Africa, and elsewhere specifically for the K13 C580Y strain, so other countries can switch drugs quickly if needed. But Dondorp and others predict “mefloquine resistance will emerge quickly,” as will resistance to other partner drugs—raising the prospect of untreatable malaria.