Does hydroxychloroquine cause cirrhosis

Discussion in 'Hydroxychloroquine Sulfate' started by MariM, 04-Mar-2020.

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    Does hydroxychloroquine cause cirrhosis


    Regardless of the problem, we'd like to help you find what you're looking for. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines.

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    A wide range of diseases and conditions can damage the liver and lead to cirrhosis. Some of the causes include Chronic alcohol abuse. Chronic viral hepatitis hepatitis B, C and D Fat accumulating in the liver nonalcoholic fatty liver disease Iron buildup in the body hemochromatosis Cystic fibrosis. Can hydroxychloroquine cause liver damage? Elevated liver enzymes are a common problem in some patients being treated with hydroxychloroquine, such as patients with lupus. However, as a general rule, hydroxychloroquine is not associated with an elevation in liver enzymes when used to treat autoimmune and rheumatologic diseases. Kidney and liver disease predispose to hydroxychloroquine toxicity due to impaired clearance of the drug. Old age is hypothesized to contribute to overall risk due to the natural aging process of the retinal pigment epithelium RPE, causing the RPE to be more sensitive to toxic drugs.

    Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito.

    Does hydroxychloroquine cause cirrhosis

    Hydroxychloroquine-induced toxic hepatitis in a patient with., Hydroxychloroquine Plaquenil Success, Reviews and Side Effects

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  3. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes.

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    Cirrhosis is not likely to be present in patients whose serum ferritin level is lower than 1000 ng/mL or whose hepatic iron concentration is below 22,000 μg/g of liver wet weight. 1,9 In patients with high levels of serum ferritin, liver biopsy with quantitation of hepatic iron concentration can be helpful in planning iron depletion therapy. Jan 18, 2019 Other risk factors for Hydroxychloroquine retinal toxicity include kidney or liver disease and obesity. Obesity is a risk factor because the drug does not penetrate fat tissue so there is more of the drug in your lean body mass including your retina and its supporting cells called the retinal pigment epithelium. The mechanism is unknown. Combining telbivudine Tyzeka and hydroxychloroquine may increase the risk of unexplained muscle pain, tenderness, or weakness because both drugs cause such side effects. Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines.

     
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    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Side Effects Common, Severe, Long Term. Chloroquine myopathy and neuropathy with elevated CSF protein. Peripheral Neuropathy Differential Diagnosis and Management
     
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