Since some malaria strains are resistant to atovaquone/proguanil, it is not effective in all parts of the world. It must be taken with a fatty meal, or at least some milk, for the body to absorb it adequately—and to avoid painful stomach irritation, which proguanil frequently causes if taken without food. Can plaquenil cause low platelets Malaria treatment drugs chloroquine For treatment of uncomplicated malaria caused by chloroquine-susceptible P. falciparum, P. malariae, or P. knowlesi or treatment of uncomplicated malaria when plasmodial species not identified and infection acquired in areas where chloroquine resistance not reported, CDC recommends chloroquine or hydroxychloroquine. 143 144 Alternatively, CDC. Adult strength tablets 250 mg atovaquone; 100 mg proguanil per tablet PO once daily for 3 consecutive days. Guidelines recommend for chloroquine-resistant infections and for infections of unknown resistance; may also use for chloroquine-sensitive infections if necessary. For P. vivax infections, add primaquine phosphate. Atovaquone-proguanil Malarone is a fixed combination of the drugs atovaquone and proguanil. For travel to areas where chloroquine resistance is present, mefloquine is the only medication recommended for malaria prophylaxis during pregnancy. Studies of mefloquine use during pregnancy have found no indication of adverse effects on the fetus. Proguanil acts as a mitochondrial sensitiser and synergizes with atovaquone. Also, stomach irritation may occur if one lies down within a half hour after taking this medicine. Malarone chloroquine resistance Epidemiology of malaria and chloroquine resistance in Mizoram., Malarone atovaquone/proguanil hydrochloride dose. Plaquenil bladder infection Atovaquone/proguanil, sold under the trade names Malarone among others, is a combination of two antimalarial medication atovaquone and proguanil. It is used to treat and prevent malaria, including chloroquine-resistant malaria. It is not recommended for severe or complicated malaria. It is taken by mouth. Atovaquone/proguanil - Wikipedia. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health.. Malarone tablets & pediatric tablets. Chloroquine is not effective in Pakistan. Ten malaria parasites have become too resistant to it. Mefloquine Lariam, Mefliam, Mephaquin and many others, doxycycline Vibramycin and many others, and atovaquone/proguanil Malarone, Malanil are all effective. In areas without chloroquine resistance, prescribe proguanil 200 mg daily. In areas with chloroquine resistance, consider doxycycline or Malarone®. In theory, doxycycline can reduce the plasma concentration of anticonvulsants but there is no evidence that this happens in practice and an increase in dosage of anticonvulsants is not recommended. Should be taken when treating geriatric patients with MALARONE. malaria including areas where chloroquine resistance has been reported. Treatment of Malaria. Product Monograph.