Chloroquine treatment autophagy

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by valio70, 18-Mar-2020.

  1. svark1 Well-Known Member

    Chloroquine treatment autophagy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine, the treatment for rheumatoid arthritis, SLE, HIV and malaria for half a century, is one of the only autophagy inhibitors, whose effectiveness and safety have been proven in clinical. One of the possible outcomes of impaired autophagy is the accumulation of lipofuscin, a nondegradable oxidation product of lipids and proteins commonly found in senescent or aged cells 15, 26, 40-42. After treatment of HaCaT with CQ 60 μM, we checked for the presence of lipofuscin. Chloroquine Sigma-Aldrich, St. Louis, MO is one of many compounds which have shown to reverse autophagy by accumulating in lysosomes, disturbing the vacuolar H+ ATPase, which is responsible for lysosomal acidification and blocking autophagy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine treatment autophagy

    Chloroquine inhibits autophagic flux by decreasing., In vitro autophagy modulation with chloroquine some.

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  3. Autophagy also promotes the survival of cells resistant to apoptosis when they are deprived of extracellular nutrients or growth factors. Treatment of such cells dependent on autophagy for survival with the drug chloroquine CQ results in brisk cell death 9.

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    Assessment of Chloroquine Treatment for Modulating Autophagy Flux in Brain of WT and HD Mice. Article PDF Available in Journal of Huntington's disease 32159-174 July 2014 with 1,235 Reads Chloroquine CQ, which is frequently used clinically as an antimalarial agent, is a classic inhibitor of autophagy that blocks the binding of autophagosomes to lysosomes by altering the acidic environment of lysosomes, resulting in the accumulation of a large number of degraded proteins in cells. This was not the case with chloroquine administration. Additionally, our VCP patients’ myoblasts depicted increased TUNEL+ upon treatment with chloroquine, but not rapamycin treatment. These studies suggest an important link between apoptotic cell death and autophagy stimulation in skeletal muscle, currently under further investigation.

     
  4. : September 14, 2016 Chief complaint: Whirling and flashing lights A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. Adherence Patterns to American Academy of Ophthalmology. New Plaquenil Guidelines Monitoring for hydroxychloroquine retinopathy Eye
     
  5. Streamer Well-Known Member

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