If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Mechanism of action of hydroxychloroquine in rheumatoid arthritis Chloroquine boots A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. This is represented by the yellow line in the above graph. Since the ideal weight is independent of her true weight the yellow line is perfectly horizontal. By this standard, a 5’4" woman’s ideal plaquenil dose is always 356 mg/day or less. Comparing the yellow line ideal weight to the other two lines. A total dose representing 25 mg of base per kg of body weight is administered in three days, as follows First dose 10 mg base per kg but not exceeding a single dose of 620 mg base. Second dose 5 mg base per kg but not exceeding a single dose of 310 mg base 6 hours after first dose. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dosing ideal body weight Early Plaquenil Toxicity Detected without Bull’s Eye., Changes to plaquenil risk calculations You use aralen for whatChloroquine phosphate molecular weightAlternatives to hydroxychloroquine for arthritisPlaquenil bone marrowPlaquenil and radiation therapy toxiciy The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. One kilogram kg equals 2.2 pounds. Women with lupus who are OVER their ideal body weight should go by these dosing rules Protecting your eyesight when taking Plaquenil Lupus.. DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet. NEW DOSE RECOMMENDATIONS FOR PLAQUENIL. - Lupus.. The typical dose for hydroxychloroquine is 200-400mg per day and is based on a person’s body weight or if you are overweight, your ideal body weight. While hydroxychloroquine is considered a relatively safe medication, like all medications there are potential risks. These include body rashes that often will itch. Furthermore, the co-authors found that the prevalence of toxicity relative to real body weight dosing was independent of body habitus, while thin individuals dosed by ideal body weight had a much. Regarding hydroxychloroquine levels and lupus activity, Costedoat- Chalumeau et al 24 measured whole blood levels in 143 individuals taking a standard dose of 400 mg per day and found a lower hydroxychloroquine level in those with active disease and that lower baseline levels were predictive of disease flare.