What is putative chloroquine transporter

Discussion in 'Health Canada Drug Database' started by ilovebig, 25-Feb-2020.

  1. Pravilnaya Moderator

    What is putative chloroquine transporter


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The complete sequencing of bacterial genomes has revealed a large number of drug transporter genes. In Escherichia coli, there are 37 open reading frames ORFs assumed to be drug transporter genes on the basis of sequence similarities, although the transport capabilities of most of them have not been established yet. We cloned all 37 putative drug transporter genes in E. coli and. May regulate endogenous transporter. UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents. The Chloroquine Resistance Transporter PfCRT was originally identified because mutations in this protein confer chloroquine resistance in the human malaria parasite, Plasmodium falciparum. However, the mechanism by which they do so has been the subject of ongoing debate. Martin et al. p.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is putative chloroquine transporter

    How chloroquine works to treat malaria Robert Baxter Electric, CG10 - Putative chloroquine resistance transporter.

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  5. Plasmodium falciparum chloroquine resistance transporter Pfcrt gene at codon 76 and multidrug resistance gene 1 Pfmdr1 at codon 86 were investigated among 406 children with uncomplicated malaria presenting at five sentinel health centres in Ghana.

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    Chloroquine-resistant cells efflux chloroquine at 40 times the rate of chloroquine-sensitive cells; the related mutations trace back to transmembrane proteins of the digestive vacuole, including sets of critical mutations in the P. falciparum chloroquine resistance transporter PfCRT gene. Sep 15, 2001 In P. falciparum the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Rapid diagnostic assays for PfCRT mutations are already employed as surveillance tools for drug resistance. The key mutation seems to be K76T since no chloroquine resistant isolate carries the wild type lysine at place seventy six. It must be famous that normally a variety of different mutations are famous in chloroquine resistant malaria, however solely the K76T amino acid change is seen constantly within the chloroquine resistant malaria.

     
  6. energo Moderator

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  7. agk Moderator

    Medicines for the Prevention of Malaria While Traveling. Both adults and children should take one dose of chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt.

    WHO Responding to antimalarial drug resistance
     
  8. G13b New Member

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