Oftentimes, you can reduce your risk for future bruising by making sure you’re getting the right nutrients in your diet. Read on to learn more about common causes, what to watch for, and when to see a doctor. Rosuvastatin and hydroxychloroquine Plaquenil and liver enzymes Bruising easily? Plaquenil? Just lupus in general? I’ve been on plaquenil for about 1.5 months now and I’m noticing I’ve been bruising so easily. I’ve always bruised pretty easily but they’re fairly superficial bruises, not very painful, and go away pretty quickly. Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include I've taken Plaquenil for aprx 9 years. I have many complications w the diseases themselves but i bruise very easily. I also notice bruises that I cant explain. They all seem to be extra sore and very bright blue. I've ask my RA Dr about this but never a understandable explanation. Most of my bruising is found on my arms, hands and lower legs. If you’ve recently overdone it at the gym, you may develop bruises around the affected muscles. Intense exercise can leave you with more than just sore muscles. Can plaquenil cause bruising Bruises and Blood Spots Under the Skin Michigan Medicine, Hydroxychloroquine Side Effects, Dosage, Uses, and More Corticosteroids vs plaquenil Some antacids can make it harder for your body to absorb hydroxychloroquine. What other drugs will affect hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Hydroxychloroquine can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Has anyone taking Plaquenil ever experienced bruising.. Lupus and Bruising DailyStrength. Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.