Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Taking too much hydroxychloroquine Hydroxychloroquine monitoring requirements Hydroxychloroquine retinopathy risk Plaquenil keep you awake Morning stiffness helps to differentiate osteoarthritis from rheumatoid arthritis. With rheumatoid arthritis, joint stiffness may not improve for several hours or it may last throughout the entire day. How is Osteoarthritis Treated? Treatment for osteoarthritis includes lifestyle changes and medications. Plaquenil and Joint pain - from FDA reports Summary Joint pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. Severe foot and ankle joint pain. MIBeth posted I'm currently taking plaquenil and tramadol, but am having so much pain in my feet, ankles, knees and wrists. I've tried heat, ice, massage, motrin, etc. and nothing seems to help. Does someone have a secret remedy to deal with this pain. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil for joint pain in oeds Hydroxychloroquine effectiveness in reducing symptoms of hand., Will you have Joint pain with Plaquenil - eHealthMe Chloroquine pigmentation Find user ratings and reviews for Plaquenil oral on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction Plaquenil oral Reviews and User Ratings Effectiveness.. Severe foot and ankle joint pain" Lupus Community.. Hydroxychloroquine Plaquenil. User Reviews for Plaquenil to treat Rheumatoid Arthritis. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Osteoarthritis OA is the most common type of arthritis, causing significant joint pain and disability. It is already a major cause of healthcare expenditure and its incidence will further increase with the ageing population. Current treatments for OA have major limitations and new analgesic treatments are needed. Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain.