It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Chloroquine resistant and sensitive areas How does chloroquine prevent malaria But take this advice Don’t ignore changes in vision. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Ok I'll admit I'm impatient to feel better and get on with my life. My question is, how long does it take for plaquenil to make an impact? And does it really help the fatigue? That's my biggest issue. I've been on it for about three and a half weeks. Thanks! Danni Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. How long does plaquenil take to work RA and Hydroxychloroquine How Effective is it for., When does the plaquenil kick in? DailyStrength Chloroquine is ineffective on the exoeryhtoChloroquine plus primaquineChloroquine phosphate injection Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It does not work against certain. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Hydroxychloroquine Plaquenil -. Plaquenil Uses, Dosage & Side Effects -. Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. User Reviews for Plaquenil to treat Rheumatoid Arthritis. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. How long does it take for plaquenil to work? I just started about 6 weeks ago, the rheum said it can take up to a year. Let me know how you are doing on it.