One class of medications can lead to more severe vision loss in people with the wet form of the disease, and another class of drugs may have a beneficial effect. Fortunately, very few prescription drugs have any known detrimental effects for people with AMD. Hg wang chloroquine Hydroxychloroquine autophagy inhibitor Because the patient has previous macular pathology, should we make a recommendation to stop the Plaquenil? It’s an important question to address, because pre-existing macular pathology is a risk factor for the development of retinal toxicity according to the new screening recommendations. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications. What is Plaquenil or hydroxychloroquine? Hydroxychoroquine is an oral medication used for the treatment of rheumatologic conditions like lupus systemic lupus erythematosus – SLE, rheumatoid arthritis and other inflammatory conditions. Doctors often put patients with certain potentially life-threatening cardiovascular conditions on this blood thinner. Warfarin (Coumadin®), which is an anticoagulant blood thinner, is one exception. Using plaquenil in end stage macular degeneration What about Plaquenil and Macular Degeneration? - Inspire, Protecting your eyesight when taking Plaquenil Lupus. Is plaquenil dangerousin myasthenia gravis Join us in the fight to end brain and eye disease. As many as 11 million people in the United States have some form of age-related macular degeneration. This number is expected to double to nearly 22 million by 2050. We're the leading nonprofit funder of research for the advanced form of macular degeneration. Prescription Medications That Can Affect Age-Related Macular.. Plaquenil - Eye Doctor MD. Medication Cautions in Macular Degeneration - AMDF. Hi this is my first post. I am on Plaquenil and have been only for 3-4 years now. I have noticed that my eyesight is getting worse. I went to my eye doctor 6 months ago and I was using cheater glasses at 150 strength and I complained about them not seeming strong enough which they weren't they should have been 200 strength. Jan 01, 2020 Significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems.