Synthesis of chloroquine from 4 7-dichloroquinoline

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  1. Wiperaider New Member

    Synthesis of chloroquine from 4 7-dichloroquinoline


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    That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures. share improve this answer Mediates 3, 4 were obtained by aromatic nucleophilic substitution of 4,7-dichloroquinoline with the appropriate aniline derivatives in ethanol and refluxing. Attachment of the lateral α,β-unsaturated side chain of compounds 5–19 was accomplished in one step reaction of Predicted data is generated using the US Environmental Protection Agency’s EPISuite™. Log Octanol-Water Partition Coef SRC Log Kow KOWWIN v1.67 estimate = 3.43 Log Kow Exper. database match = 3.57 Exper.

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    Synthesis of chloroquine from 4 7-dichloroquinoline

    Chapter-1 Design, synthesis and antimalarial activity of 4., Synthesis of 7-Chloroquinolin-4-ylaminochalcones.

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  3. Synthesis of New Chloroquine Derivatives as Antimalarial Agents. 4,7-dichloroquinoline 25.35 g, 0. 128 mol and 3-aminopro-. Synthesis of new Chloroquine Derivatives 541.

    • PDF Synthesis of New Chloroquine Derivatives as Antimalarial Agents.
    • Dichloroquinoline C9H5Cl2N ChemSpider.
    • A New Synthesis of Chloroquine Journal of the American Chemical Society.

    Chloroquine and its metabolites were prepared from 7‐chloro‐1,2,3,4‐tetrahydroquinolin‐4‐one through an aryl substitution with the corresponding amines; and the amodiaquine and its metabolites were prepared from 4,7‐dichloroquinoline in a similar fashion. The synthesis of various 4-aminoquinoline antimalarials may be achieved by nucleophilic reaction of 91 with desired amines. Scheme 2 outlines the preparation of chloroquine 3 and amodiaquine 8 starting from 4,7-dichloroquinoline 91 134–136. Dichloroquinoline - cas 86-98-6, synthesis, structure, density, melting point, boiling point

     
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  5. Mariotti Well-Known Member

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    Chloroquine Indications, Side Effects, Warnings -