Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Chloroquine-induced pigmentation Plaquenil sjogrens syndrome Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Taking methotrexate with hydroxychloroquine has not been studied. It may increase your risk of side. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. Check the latest outcomes from 354,175 Methotrexate users, or browse all drugs. What is Plaquenil? Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate and plaquenil Perioperative management of the patient with rheumatoid arthritis, Effects of methotrexate and hydroxychloroquine combination therapy vs. Plaquenil capsulePlaquenil bladder infections In defense of your ophthalmologist, the eye problems with Plaqueni, although rare are dose related. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have other medical problems, one drug might be better for you and you should discuss this with your rheumatologist. Plaquenil vs Methotrexate Antineoplastics Cancer drugs.. Methotrexate and Plaquenil drug interactions - eHealthMe. Methotrexate vs Plaquenil Comparison -. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. Methotrexate and plaquenil. now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. i am still in so much pain everyday and hoping for some relieve soon. I'm on methotrexate too now but was on a different immunosuppressant for 18mths before that. Being immune suppressed freaked me out at the start n I thought I'd pick up infection really quickly. I haven't. hubby's had a couple of colds n I've been ok. Im on plaquenil, cellcept AND tacrolimus--finally helping my lupus nephritis and as.