Chloroquine resistance mechanism of action

Discussion in 'Canadian Ed Drugstore' started by Rusreach, 04-Mar-2020.

  1. angee Well-Known Member

    Chloroquine resistance mechanism of action


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The mechanisms of chloroquine accumulation in the food vacuole have been proposed to be accumulation of chloroquine in the food vacuole as a result of increased acidity, presence of a carrier in the parasite and the presence of a receptor in the vacuole that chloroquine can bind to 10. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistance mechanism of action

    Chloroquine-Resistant Malaria The Journal of Infectious., Chloroquine - Wikipedia

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  4. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells.

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    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect. Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen.

     
  5. dmsoh User

    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Hydroxychloroquine Tablets - FDA prescribing information. Chloroquine Price of 213 Brands / Trade Names Medindia Drug - Chloroquine Phosphate-250 mg 250mg - 10 Tablets Tablet.
     
  6. Hydroxychloroquine Oral Route Description and Brand Names. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria.

    Adverse Cutaneous Reactions to Hydroxychloroquine Are More.
     
  7. senserens Guest

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